Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction
نویسندگان
چکیده
منابع مشابه
Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction
An efficient, two-step construction of highly complex alkaloid-like compounds from the natural product fumagillol is described. This approach, which mimics a biosynthetic cyclase/oxidase sequence, allows for rapid and efficient structure elaboration of the basic fumagillol scaffold with a variety of readily available coupling partners. Mechanistic experiments leading to the discovery of an oxyg...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2014
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol4035269